Synthesis and Pharmacological Properties of Silicon-Containing 1,4-Dihydropyridine Derivatives: Calcium Channel Antagonists and α1 Adrenoceptor Antagonists of the Sila-niguldipine Type
Author:
Affiliation:
1. Institut für Anorganische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany, and Amedis Pharmaceuticals Ltd., 162 Cambridge Science Park, Milton Road, Cambridge CB4 0GP, U.K.
Publisher
American Chemical Society (ACS)
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/om0305622
Reference24 articles.
1. Re-examining the Clinical Safety and Roles of Calcium Antagonists in Cardiovascular Medicine
2. The pharmacology of ion channels: with particular reference to voltage-gated Ca2+ channels
3. (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors
4. Discovery of .alpha.1a-Adrenergic Receptor Antagonists Based on the L-Type Ca2+ Channel Antagonist Niguldipine
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