Synthesis and Discovery of N-Carbonylpyrrolidine- or N-Sulfonylpyrrolidine-Containing Uracil Derivatives as Potent Human Deoxyuridine Triphosphatase Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Discovery of N-Carbonylpyrrolidine- or N-Sulfonylpyrrolidine-Containing Uracil Derivatives as Potent Human Deoxyuridine Triphosphatase Inhibitors

Published:2012-03-26 Issue:7 Volume:55 Page:2960-2969
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miyakoshi Hitoshi¹²,Miyahara Seiji¹³,Yokogawa Tatsushi¹,Chong Khoon Tee¹,Taguchi Junko¹,Endoh Kanji¹,Yano Wakako¹,Wakasa Takeshi¹,Ueno Hiroyuki¹,Takao Yayoi¹,Nomura Makoto¹,Shuto Satoshi³,Nagasawa Hideko²,Fukuoka Masayoshi¹

Affiliation:

1. Drug Discovery Research Center, Taiho Pharmaceutical Co. Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

2. Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan

3. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201627n

Reference42 articles.

1. Thymidylate synthase: A target for anticancer drug design