Development of an Effective Palladium Removal Process for VEGF Oncology Candidate AG13736 and a Simple, Efficient Screening Technique for Scavenger Reagent Identification-Reference-Cited by-同舟云学术

Development of an Effective Palladium Removal Process for VEGF Oncology Candidate AG13736 and a Simple, Efficient Screening Technique for Scavenger Reagent Identification

Published:2008-07-01 Issue:4 Volume:12 Page:637-645
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Flahive Erik J.¹,Ewanicki Brigitte L.¹,Sach Neal W.¹,O’Neill-Slawecki Stacy A.¹,Stankovic Nebojsa S.¹,Yu Shu¹,Guinness Steven M.¹,Dunn Jonathan¹

Affiliation:

1. Chemical Reseach and Development, Pfizer Global R&D, 10578 Science Center Drive, San Diego, California 92121, U.S.A., Chemical Research and Development, Pfizer Global R&D, Eastern Point Road, Building 100, Groton, Connecticut 06340 U.S.A., Chemical Reseach and Development, Pfizer Global R&D, Ramsgate Road, Sandwich, England CT13 9NJ, Analytical Reseach and Development, Pfizer Global R&D, 10578 Science Center Drive, San Diego California, 92121, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op600280g

Reference15 articles.

1. Vascular Endothelial Growth Factor as a Target for Anticancer Therapy

2. Steps for the purpose of this comparison include only bond-forming reactions, regardless of whether steps are combined in a single-pot operation. Both syntheses include endgame processing steps to remove residual heavy metals, achieve chemical purification and effect control of the final polymorphic form. The purpose of this paper is to discuss work toward an effective palladium removal process; discussion of the preceding chemistry and polymorph control steps are beyond the scope of this manuscript.

3. The Art of Meeting Palladium Specifications in Active Pharmaceutical Ingredients Produced by Pd-Catalyzed Reactions

4. Removal of Metals from Process Streams: Methodologies and Applications

5. A separate manuscript detailing the development of the chemistry for the synthesis depicted in Scheme1is planned.

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