Hyperpolarized (1-13C)Alaninamide Is a Multifunctional In Vivo Sensor of Aminopeptidase N Activity, pH, and CO2

Author:

Radaelli Alice1,Ortiz Daniel2,Michelotti Alessia3,Roche Maxime3ORCID,Hata Ryunosuke4,Sando Shinsuke4,Bonny Olivier5,Gruetter Rolf1,Yoshihara Hikari A. I.1ORCID

Affiliation:

1. Laboratory for Functional and Metabolic Imaging (LIFMET), Institute of Physics, EPFL, 1015Lausanne, Switzerland

2. Mass Spectrometry Platform, Institute of Chemical Sciences and Engineering (ISIC), EPFL, 1015Lausanne, Switzerland

3. CortecNet, 7 Avenue du Hoggar, 91940Les Ulis, France

4. Department of Chemistry and Biotechnology, The University of Tokyo, Tokyo113-8656, Japan

5. Service of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), 1011Lausanne, Switzerland

Funder

Centre d'Imagerie BioM?dicale

Staatssekretariat f?r Bildung, Forschung und Innovation

H2020 Marie Sklodowska-Curie Actions

Louis-Jeantet Foundation

Publisher

American Chemical Society (ACS)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Instrumentation,Bioengineering

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