Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies

Author:

Chou Chao-Kai1,Liu Yen-Liang23ORCID,Chen Yuan-I3,Huang Po-Jung4ORCID,Tsou Pei-Hsiang1,Chen Chun-Te1,Lee Heng-Huan1,Wang Ying-Nai1,Hsu Jennifer L.1,Lee Jin-Fong1,Yankeelov Thomas E.35678,Kameoka Jun49,Yeh Hsin-Chih310ORCID,Hung Mien-Chie12111213

Affiliation:

1. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States

2. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan 40402

3. Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States

4. Department of Materials Science and Engineering, Texas A&M University, College Station, Texas 77840, United States

5. Institute for Computational Engineering and Sciences, The University of Texas, Austin, Texas 78712, United States

6. Department of Diagnostic Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas 78712, United States

7. Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, Texas 78712, United States

8. Livestrong Cancer Institutes, The University of Texas at Austin, Austin, Texas 78712, United States

9. Department of Electrical and Computer Engineering, Texas A&M University, College Station, Texas 77843, United States

10. Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712, United States

11. Center for Molecular Medicine, China Medical University, Taichung, Taiwan 40402

12. Cancer Biology Program, Graduate School of Biomedical Sciences, The University of Texas Health Sciences Center at Houston, Houston, Texas 77030, United States

13. Department of Biotechnology, Asia University, Taichung, Taiwan 41354

Funder

Division of Chemistry

National Breast Cancer Foundation

National Cancer Institute

Welch Foundation

Ministry of Health and Welfare

National Institute of Allergy and Infectious Diseases

China Medical University

Breast Cancer Research Foundation

Cancer Prevention and Research Institute of Texas

Ministry of Science and Technology, Taiwan

National Institute of General Medical Sciences

University of Texas MD Anderson Cancer Center

Patel Memorial Breast Cancer Endowment Fund

Texas 4000

Publisher

American Chemical Society (ACS)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Instrumentation,Bioengineering

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