High-Risk Long QT Syndrome Mutations in the Kv7.1 (KCNQ1) Pore Disrupt the Molecular Basis for Rapid K+ Permeation

Author:

Burgess Don E.1,Bartos Daniel C.1,Reloj Allison R.1,Campbell Kenneth S.1,Johnson Jonathan N.2,Tester David J.2,Ackerman Michael J.2,Fressart Véronique34,Denjoy Isabelle34,Guicheney Pascale34,Moss Arthur J.5,Ohno Seiko6,Horie Minoru6,Delisle Brian P.1

Affiliation:

1. Center for Muscle Biology, Department of Physiology, University of Kentucky, 800 Rose Street, MS508, Lexington, Kentucky 40536, United States

2. Departments of Medicine, Pediatrics, and Molecular Pharmacology and Experimental Therapeutics/Divisions of Cardiovascular Diseases and Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota 55905, United States

3. INSERM, U956, Hôpital Pitié-Salpêtrière, Fondation ICAN, Paris, France

4. UPMC Univ Paris 06, UMR_S956, IFR14, Paris, France

5. Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, United States

6. Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Sciences, Seta-tsukinowa, Ohtsu 520-2192, Japan

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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