17β-O-Aminoalkyloximes of 5β-Androstane-3β,14β-diol with Digitalis-like Activity: Synthesis, Cardiotonic Activity, Structure−Activity Relationships, and Molecular Modeling of the Na+,K+-ATPase Receptor-Reference-Cited by-同舟云学术

17β-O-Aminoalkyloximes of 5β-Androstane-3β,14β-diol with Digitalis-like Activity: Synthesis, Cardiotonic Activity, Structure−Activity Relationships, and Molecular Modeling of the Na+,K+-ATPase Receptor

Published:2000-05-17 Issue:12 Volume:43 Page:2332-2349
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cerri Alberto¹,Almirante Nicoletta¹,Barassi Paolo¹,Benicchio Alessandra¹,Fedrizzi Giorgio¹,Ferrari Patrizia¹,Micheletti Rosella¹,Quadri Luisa¹,Ragg Enzio¹,Rossi Roberto¹,Santagostino Marco¹,Schiavone Antonio¹,Serra Fulvio¹,Zappavigna Maria Pia¹,Melloni Piero¹

Affiliation:

1. Departments of Medicinal Chemistry and Cardiovascular Pharmacology, Prassis Istituto di Ricerche Sigma-Tau, Via Forlanini 3, 20019 Settimo Milanese (MI), Italy, and Department of Agricultural and Food Molecular Science, Chemistry Section, Faculty of Agriculture, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990627w

Reference37 articles.

1. Synthesis and Quantitative Structure−Activity Relationships of 17β-(Hydrazonomethyl)-5β-androstane-3β,14β-diol Derivatives That Bind to Na+,K+-ATPase Receptor

2. Synthesis, Cardiotonic Activity, and Structure−Activity Relationships of 17β-Guanylhydrazone Derivatives of 5β-Androstane-3β,14β-diol Acting on the Na+,K+-ATPase Receptor

3. A New Approach to the Design of Novel Inhibitors of Na+,K+-ATPase: 17α-Substituted Seco-D 5β-Androstane as Cassaine Analogues

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