Selection of Evodiamine as a Novel Topoisomerase I Inhibitor by Structure-Based Virtual Screening and Hit Optimization of Evodiamine Derivatives as Antitumor Agents
Author:
Affiliation:
1. Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People’s Republic of China
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm100387d
Reference62 articles.
1. Topoisomerase I inhibitors: camptothecins and beyond
2. Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA.
3. DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
4. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
5. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2
Cited by 123 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Design, synthesis, and biological evaluation of harmine derivatives as topoisomerase I inhibitors for cancer treatment;European Journal of Medicinal Chemistry;2024-02
2. Design, synthesis and bioactivity evaluation of the combination of evodiamine and erlotinib linked by indolequinone;Bioorganic & Medicinal Chemistry Letters;2024-02
3. Natural products fragment-based design and synthesis of a novel pentacyclic ring system as potential MAPK inhibitor;Bioorganic & Medicinal Chemistry Letters;2024-02
4. Natural products fragment-based design and synthesis of a novel pentacyclic ring system as potential MAPK Inhibitor;2023-10-06
5. PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders;Journal of Advanced Research;2023-10
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3