Design and Synthesis of Conformationally Constrained Grb2 SH2 Domain Binding Peptides Employing α-Methylphenylalanyl Based Phosphotyrosyl Mimetics-Reference-Cited by-同舟云学术

Design and Synthesis of Conformationally Constrained Grb2 SH2 Domain Binding Peptides Employing α-Methylphenylalanyl Based Phosphotyrosyl Mimetics

Published:2005-01-19 Issue:3 Volume:48 Page:764-772
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Oishi Shinya¹,Karki Rajeshri G.¹,Kang Sang-Uk¹,Wang Xiangzhu¹,Worthy Karen M.¹,Bindu Lakshman K.¹,Nicklaus Marc C.¹,Fisher Robert J.¹,Burke Terrence R.¹

Affiliation:

1. Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, and Protein Chemistry Laboratory, Science Applications International CorporationFrederick, Frederick, Maryland 21702

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0492709

Reference29 articles.

1. Multiple Grb2-protein complexes in human cancer cells

2. The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase

3. Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer

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