Potent Dibasic GPIIb/IIIa Antagonists with Reduced Prolongation of Bleeding Time: Synthesis and Pharmacological Evaluation of 2-Oxopiperazine Derivatives-Reference-Cited by-同舟云学术

Potent Dibasic GPIIb/IIIa Antagonists with Reduced Prolongation of Bleeding Time: Synthesis and Pharmacological Evaluation of 2-Oxopiperazine Derivatives

Published:2001-06-21 Issue:15 Volume:44 Page:2438-2450
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kitamura Shuji¹,Fukushi Hideto¹,Miyawaki Toshio¹,Kawamura Masaki¹,Konishi Noriko¹,Terashita Zen-ichi¹,Naka Takehiko¹

Affiliation:

1. Medicinal Chemistry Research Laboratories II, Medicinal Chemistry Research Laboratories I, and Pharmacology Research Laboratories I, Takeda Chemical Industries, Ltd., 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8386, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0004345

Reference21 articles.

1. Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.

2. The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

3. The platelet membrane glycoprotein IIb-IIIa complex

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