Structural Determinants of Insulin Release: Disordered N-Terminal Tail of Kir6.2 Affects Potassium Channel Dynamics through Interactions with Sulfonylurea Binding Region in a SUR1 Partner-Reference-Cited by-同舟云学术

Structural Determinants of Insulin Release: Disordered N-Terminal Tail of Kir6.2 Affects Potassium Channel Dynamics through Interactions with Sulfonylurea Binding Region in a SUR1 Partner

Published:2020-06-29 Issue:29 Volume:124 Page:6198-6211
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Walczewska-Szewc Katarzyna¹²,Nowak Wiesław¹^ORCID

Affiliation:

1. Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziądzka 5, 87-100 Toruń, Poland

2. Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, Wileńska 4, 87-100 Toruń, Poland

Funder

National Science Centre, Poland

Interdisciplinary Centre for Mathematical and Computational Modelling (ICM) University of Warsaw

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.0c02720

Reference63 articles.

1. Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

2. ATP-sensitive potassium channelopathies: focus on insulin secretion

3. Neonatal Diabetes and the K ATP Channel: From Mutation to Therapy

4. Hyperinsulinism in Infancy: From Basic Science to Clinical Disease

5. Spacial models of malfunctioned protein complexes help to elucidate signal transduction critical for insulin release

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