How Does the Spliceosome Catalyze Intron Lariat Formation? Insights from Quantum Mechanics/Molecular Mechanics Free-Energy Simulations-Reference-Cited by-同舟云学术

How Does the Spliceosome Catalyze Intron Lariat Formation? Insights from Quantum Mechanics/Molecular Mechanics Free-Energy Simulations

Published:2019-06-19 Issue:28 Volume:123 Page:6049-6055
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Huang Wenting¹,Huang Yan¹,Xu Jun²,Liao Jie-Lou¹^ORCID

Affiliation:

1. Department of Chemical Physics, University of Science and Technology of China, JinZhai Rd. 96, Hefei, Anhui 230026, China

2. Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, 132 East Circle at University City, Guangzhou 510006, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.9b04377

Reference57 articles.

1. Spliceosome Structure and Function

2. Structural basis of pre-mRNA splicing

3. CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing

4. The Spliceosome: Design Principles of a Dynamic RNP Machine

5. Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

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