Conformational Substrate Selection Contributes to the Enzymatic Catalytic Reaction Mechanism of Pin1
Author:
Affiliation:
1. Departamento de Físico-Química, Facultad de Ciencias Químicas, Universidad de Concepción, 4030000 Concepción, Chile
Funder
Ministerio de Economía, Fomento y Turismo
Fondo Nacional de Desarrollo Científico y Tecnológico
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.6b09187
Reference36 articles.
1. At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?
2. Enzyme dynamics point to stepwise conformational selection in catalysis
3. The catalytic power of enzymes: Conformational selection or transition state stabilization?
4. Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? The Diverse Functional Roles of Conformational Ensembles in the Cell
5. How Does Pin1 Catalyze the Cis–Trans Prolyl Peptide Bond Isomerization? A QM/MM and Mean Reaction Force Study
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