Antimicrobial Peptide Mechanism Studied by Scattering-Guided Molecular Dynamics Simulation

Author:

Allsopp Robert1,Pavlova Anna2,Cline Tyler1,Salyapongse Aria M.3,Gillilan Richard E.4,Di Y. Peter5ORCID,Deslouches Berthony5,Klauda Jeffery B.1ORCID,Gumbart James C.2ORCID,Tristram-Nagle Stephanie3ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States

2. School of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332, United States

3. Biological Physics Group, Physics Department, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States

4. Cornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, New York 14853, United States

5. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

Funder

Carnegie Mellon University

National Institutes of Health

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Reference67 articles.

1. WHO. Antimicrobial Resistance WHO Global Report on Surveillance, 2014, http://www.who.int/drugresistance/documents/surveillancereport/en/.

2. O’Niell, J. Tackling Drug-resistant Infections Globally: Final Report and Recommendations; United Kingdom, 2016; pp 1–84.

3. LL-37, the only human member of the cathelicidin family of antimicrobial peptides

4. Activity of the De Novo Engineered Antimicrobial Peptide WLBU2 against Pseudomonas aeruginosa in Human Serum and Whole Blood: Implications for Systemic Applications

5. Lentivirus-derived antimicrobial peptides: increased potency by sequence engineering and dimerization

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