Calmodulin (CaM) Activates PI3Kα by Targeting the “Soft” CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α-Reference-Cited by-同舟云学术

Calmodulin (CaM) Activates PI3Kα by Targeting the “Soft” CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α

Published:2018-07-26 Issue:49 Volume:122 Page:11137-11146
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Zhang Mingzhen¹^ORCID,Li Zhigang²,Wang Guanqiao³,Jang Hyunbum¹^ORCID,Sacks David B.²,Zhang Jian³^ORCID,Gaponenko Vadim⁴,Nussinov Ruth¹⁵

Affiliation:

1. Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, Maryland 21702, United States

2. Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland 20892, United States

3. Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China

4. Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, United States

5. Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

Funder

U.S. Department of Health and Human Services

Frederick National Laboratory for Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.8b05982

Reference61 articles.

1. The PI3K Pathway in Human Disease

2. The Phosphoinositide 3-Kinase Pathway

3. Targeting the phosphoinositide 3-kinase pathway in cancer

4. Drugging PI3K in cancer: refining targets and therapeutic strategies

5. Unraveling structural mechanisms of allosteric drug action

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