Dynamics of the Proline-Rich C-Terminus of Huntingtin Exon-1 Fibrils
Author:
Affiliation:
1. Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, 1501 San Pablo St., Los Angeles, California 90033, United States
Funder
National Institute of Neurological Disorders and Stroke
CHDI Foundation
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.8b09213
Reference49 articles.
1. Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
2. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
3. Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation
4. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
5. Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils
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