Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR-Reference-Cited by-同舟云学术

Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR

Published:2021-03-15 Issue:11 Volume:125 Page:2929-2941
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Amos Sarah-Beth T. A.¹,Schwarz Thomas C.²,Shi Jiye³,Cossins Benjamin P.³,Baker Terry S.³,Taylor Richard J.³,Konrat Robert²,Sansom Mark S. P.¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

2. Department of Structural and Computational Biology, Max Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, Vienna A-1030, Austria

3. UCB Pharma, 208 Bath Road, Slough SL1 3WE, U.K.

Funder

Engineering and Physical Sciences Research Council

Partnership for Advanced Computing in Europe AISBL

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.1c01281

Reference93 articles.

1. The Synucleinopathies: Twenty Years On

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3. α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

4. Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells

5. -Synuclein Negatively Regulates Protein Kinase C Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

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