Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis–Trans Isomerization and the Chameleonic Roles of Calcium-Reference-Cited by-同舟云学术

Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis–Trans Isomerization and the Chameleonic Roles of Calcium

Published:2021-02-01 Issue:5 Volume:125 Page:1378-1391
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Gray Amber L. H.¹^ORCID,Steren Carlos A.¹,Haynes Isaac W.¹,Bermejo Guillermo A.²,Favretto Filippo³,Zweckstetter Markus³⁴,Do Thanh D.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996, United States

2. Computational Biomolecular Magnetic Resonance Core, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States

3. Translational Structural Biology in Dementia, German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075 Göttingen, Germany

4. Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.0c11152

Reference85 articles.

1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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