Theoretical Investigation on the Elusive Reaction Mechanism of Spirooxindole Formation Mediated by Cytochrome P450s: A Nascent Feasible Charge-Shift C–O Bond Makes a Difference-Reference-Cited by-同舟云学术

Theoretical Investigation on the Elusive Reaction Mechanism of Spirooxindole Formation Mediated by Cytochrome P450s: A Nascent Feasible Charge-Shift C–O Bond Makes a Difference

Published:2021-07-27 Issue:30 Volume:125 Page:8419-8430
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Chen Huanhuan¹²,Zhou Anran¹²,Sun Dongru¹²,Zhao Yufen¹²,Wang Yong¹²^ORCID

Affiliation:

1. Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, Zhejiang, China

2. Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo 315211, Zhejiang, China

Funder

Natural Science Foundation of Ningbo

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.1c04088

Reference90 articles.

1. Refactoring the Concise Biosynthetic Pathway of Cyanogramide Unveils Spirooxindole Formation Catalyzed by a P450 Enzyme

2. Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues

3. Orbicularisine: A Spiro-Indolothiazine Isolated from Gills of the Tropical Bivalve Codakia orbicularis

4. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells

5. Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles

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