Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain

Author:

Monti Michele12,Milanetti Edoardo23ORCID,Frans Myrthe T.4,Miotto Mattia2,Di Rienzo Lorenzo2,Baranov Maksim V.4,Gosti Giorgio25,Somavarapu Arun Kumar6,Nagaraj Madhu6,Golbek Thaddeus W.7ORCID,Rossing Emiel8ORCID,Moons Sam J.8ORCID,Boltje Thomas J.8ORCID,van den Bogaart Geert4ORCID,Weidner Tobias7ORCID,Otzen Daniel E.6ORCID,Tartaglia Gian Gaetano12ORCID,Ruocco Giancarlo23,Roeters Steven J.79ORCID

Affiliation:

1. RNA Systems Biology, Centre for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT), Via Enrico Melen, 83, 16152 Genova, Italy

2. Center for Life Nanoscience, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy

3. Department of Physics, Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy

4. Molecular Immunology─Groningen Biomolecular Sciences and Biotechnology, Nijenborgh 7, 9747 AG Groningen, The Netherlands

5. DHILab, Istituto di Scienze del Patrimonio Culturale, Sede di Roma, Consiglio Nazionale delle Ricerche, Via Salaria km, 29300, 00010 Rome, Italy

6. Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark

7. Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark

8. Synthetic Organic Chemistry, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands

9. Amsterdam UMC, Vrije Universiteit, Department of Anatomy and Neurosciences, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands

Funder

Novo Nordisk Fonden

EIT Health

Innovationsfonden

H2020 European Research Council

Lundbeck Foundation

Publisher

American Chemical Society (ACS)

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