The Enolization Chemistry of a Thioester-Dependent Racemase: The 1.4 Å Crystal Structure of a Reaction Intermediate Complex Characterized by Detailed QM/MM Calculations-Reference-Cited by-同舟云学术

The Enolization Chemistry of a Thioester-Dependent Racemase: The 1.4 Å Crystal Structure of a Reaction Intermediate Complex Characterized by Detailed QM/MM Calculations

Published:2012-03-07 Issue:11 Volume:116 Page:3619-3629
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Sharma Satyan¹,Bhaumik Prasenjit²,Schmitz Werner³,Venkatesan Rajaram¹,Hiltunen J. Kalervo¹,Conzelmann Ernst³,Juffer André H.¹,Wierenga Rik K.¹

Affiliation:

1. Biocenter Oulu and Department of Biochemistry, University of Oulu, P.O. Box 3000, Oulu, FI-90014, Finland

2. Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States

3. Theodor-Boveri-Institut für Biowissenschaften (Biozentrum) der Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp210185m

Reference77 articles.

1. α-Methylacyl-CoA Racemase from Mycobacterium tuberculosis

2. α-Methylacyl-CoA racemase - an ‘obscure’ metabolic enzyme takes centre stage

3. Tanner, M. E.; Kenyon, G. L.InComprehensive Biological Catalysis: A Mechanistic Reference;Sinnott, M., Ed.Academic Press:San Diego, 1998; Vol.2, pp7–42.

4. Understanding Nature's Strategies for Enzyme-Catalyzed Racemization and Epimerization

5. Mechanism of the Reaction Catalyzed by Mandelate Racemase: Importance of Electrophilic Catalysis by Glutamic Acid 317

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. α-Methylacyl-CoA Racemase from Mycobacterium tuberculosis—Detailed Kinetic and Structural Characterization of the Active Site;Biomolecules;2024-03-02

2. Phase II metabolic transformations;An Integrated Guide to Human Drug Metabolism;2024

3. Recombinant protein production for structural and kinetic studies: A case study using M. tuberculosis α-methylacyl-CoA racemase (MCR);Methods in Enzymology;2023

4. Racemases and epimerases operating through a 1,1-proton transfer mechanism: reactivity, mechanism and inhibition;Chemical Society Reviews;2021

5. Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development;Processes;2020-12-30