1. School of Bioresources, Hiroshima Prefectural University, 562, Nanatsukacyo, Syobara-shi, Hiroshima, 727-0023, Japan, School of Pharmaceutical Sciences, University of Shizuoka, 52-1, Yada, Shizuoka-shi, 422-8526, Japan, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya, Tokyo, 158-8501, Japan, and Lion Corporation, Biological Science Research Center, 100, Tajima, Odawara, 256-0811, Japan