Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal–Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer-Reference-Cited by-同舟云学术

Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal–Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

Published:2014-09-15 Issue:18 Volume:57 Page:7577-7589
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jia Hong¹,Dai Guangxiu¹,Weng Jianyang¹,Zhang Zhulin¹,Wang Qing¹,Zhou Feng¹,Jiao Longxian¹,Cui Yumin¹,Ren Yongxin¹,Fan Shiming¹,Zhou Jinghong¹,Qing Weiguo¹,Gu Yi¹,Wang Jian¹,Sai Yang¹,Su Weiguo¹

Affiliation:

1. Hutchison MediPharma Limited, Building 4, 720 Cai Lun Road, Zhangjiang Hi-Tech Park, 201203, Shanghai, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500510f

Reference25 articles.

1. Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

2. c-met Expression in Pancreatic Cancer and Effects of Hepatocyte Growth Factor on Pancreatic Cancer Cell Growth

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