Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity-Reference-Cited by-同舟云学术

Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity

Published:2015-06-02 Issue:11 Volume:58 Page:4483-4493
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tropak Michael B.¹,Zhang Jianmin²,Yonekawa Sayuri¹,Rigat Brigitte A.¹,Aulakh Virender S.²,Smith Matthew R.²,Hwang Hee-Jong²,Ciufolini Marco A.²,Mahuran Don J.¹³

Affiliation:

1. Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada

2. Department of Chemistry, University of British Columbia, 2036 Main Mall Vancouver, British Columbia V6T 1Z1, Canada

3. Department of Laboratory Medicine and Pathology, University of Toronto, Medical Science Building, 1 King’s College Circle, 6th Floor, Toronto, Ontario M5S 1A8, Canada

Funder

Canadian Institutes of Health Research

Uger Estate

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5017895

Reference30 articles.

1. Crystal structure of dihydrofolate reductase from Plasmodium vivax: Pyrimethamine displacement linked with mutation-induced resistance

2. Pyrimethamine as a Potential Pharmacological Chaperone for Late-onset Forms of GM2 Gangliosidosis