The Development of a Large-Scale Synthesis of Matrix Metalloproteinase Inhibitor, ABT-518
Author:
Affiliation:
1. Abbott Laboratories, Global Pharmaceutical R&D, Process R&D, 1401 Sheridan Road, D-R450, Building R-8, North Chicago, Illinois 60064-4000, U.S.A.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op025525l
Reference8 articles.
1. Phenoxyphenyl Sulfone N-Formylhydroxylamines (Retrohydroxamates) as Potent, Selective, Orally Bioavailable Matrix Metalloproteinase Inhibitors
2. Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis
3. The decomposition of17, a lithium ester enolate related to8b, via a β-elimination mechanism to form acetone at temperatures ≥−50 °C has been reported. Leighton J. L. Ph.D. Thesis, Harvard University, Cambridge, MA, 1994.
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