Novel Type of Prodrug Activation through a Long-Range O,N-Acyl Transfer: A Case of Water-Soluble CREB Inhibitor
Author:
Affiliation:
1. Transmed Oncology, Cave Creek, Arizona 85327, United States
2. Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, United States
Funder
Susan G. Komen for the Cure
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml500330n
Reference30 articles.
1. Targeting CREB for Cancer Therapy: Friend or Foe
2. CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
3. Transcriptional regulation by the phosphorylation-dependent factor CREB
4. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
5. Recruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation
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