Syntheses of a Selective Peroxisome Proliferator Activated Receptor Modulator and Practical New Preparations of 2-(4-Alkoxyphenyl)ethylamines

Author:

Magnus Nicholas A.1,Astleford Bret A.1,Brennan John1,Stout James R.1,Tharp-Taylor Roger W.1

Affiliation:

1. Eli Lilly and Company, Chemical Product Research and Development Division, Indianapolis, Indiana 46285, U.S.A

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference29 articles.

1. Ferritto-Crespo, R., Martin Ortega, M. D.(Eli Lilly and Co., U.S.A.).Selective Peroxisome Proliferator Activated Receptor ModulatorsPCT Int. Appl. WO 2005/061441 A1, 2004.

2. Non-thiazolidinedione antihyperglycaemic agents. Part 4: Synthesis of (±)-, (R)-(+)- and (S)-(−)-enantiomers of 2-oxy-3-arylpropanoic acids

3. bAndersson, K.; Lindstedt Alstermark, E.WO 9962870, 1999.

4. cEbdrup, S.; Deussen, H.J.; Zundel, M.Process for the preparation of substituted 3-phenyl-propanoic acid esters and substituted 3-phenyl-propanoic acids. PCT Appl. WO 0111072, 2001.

5. Novel Tricyclic-α-alkyloxyphenylpropionic Acids:  Dual PPARα/γ Agonists with Hypolipidemic and Antidiabetic Activity

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