Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening-Reference-Cited by-同舟云学术

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

Published:2016-03-08 Issue:3 Volume:56 Page:548-562
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Pavadai Elumalai,El Mazouni Farah¹,Wittlin Sergio²³,de Kock Carmen⁴,Phillips Margaret A.¹,Chibale Kelly

Affiliation:

1. Departments of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Blvd, Dallas, Texas 75390-9041, United States

2. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland

3. University of Basel, 4002 Basel, Switzerland

4. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa

Funder

National Cancer Institute

Welch Foundation

National Institute of Allergy and Infectious Diseases

National Research Foundation

South African Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.5b00680

Reference63 articles.

1. Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data

2. Chloroquine‐Resistant Malaria

3. Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites

4. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.

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