Adjusting Catalytic Activity of β-Amyrin Synthase GgBAS by Utilizing the Plasticity Residues of an Active Site-Reference-Cited by-同舟云学术

Adjusting Catalytic Activity of β-Amyrin Synthase GgBAS by Utilizing the Plasticity Residues of an Active Site

Published:2024-04-26 Issue:9 Volume:64 Page:3933-3941
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Zheng Ying¹²,Chen Nianhang³,Ji Zhongju¹⁴,Ye Qiongyu¹⁴,Huang Pingping¹⁴,Chen Xiaodie⁴,Cui Guanghong²,Duan Lixin¹⁴^ORCID,Zhang Fan¹⁴^ORCID

Affiliation:

1. Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China

2. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing 100700, P. R. China

3. School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou 510006, P. R. China

4. Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China

Funder

National Natural Science Foundation of China

Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c00297

Reference35 articles.

1. Triterpene Biosynthesis in Plants

2. The saponins – polar isoprenoids with important and diverse biological activities

3. Molecular activities, biosynthesis and evolution of triterpenoid saponins

4. Site-directed mutagenesis and substrate compatibility to reveal the structure–function relationships of plant oxidosqualene cyclases

5. Engineering Saccharomyces cerevisiae for Hyperproduction of β-Amyrin by Mitigating the Inhibition Effect of Squalene on β-Amyrin Synthase