RLpMIEC: High-Affinity Peptide Generation Targeting Major Histocompatibility Complex-I Guided and Interpreted by Interaction Spectrum-Navigated Reinforcement Learning-Reference-Cited by-同舟云学术

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RLpMIEC: High-Affinity Peptide Generation Targeting Major Histocompatibility Complex-I Guided and Interpreted by Interaction Spectrum-Navigated Reinforcement Learning

Published:2024-08-09 Issue:16 Volume:64 Page:6432-6449
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Deng Qirui¹,Wang Zhe²³,Xiang Sutong¹,Wang Qinghua¹,Liu Yifei²,Hou Tingjun²^ORCID,Sun Huiyong¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009 Jiangsu, P. R. China

2. Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058 Zhejiang, P. R. China

3. School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, P. R. China

Funder

China Pharmaceutical University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c01153

Reference92 articles.

1. Present Yourself! By MHC Class I and MHC Class II Molecules

2. Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules

3. Towards a systems understanding of MHC class I and MHC class II antigen presentation

4. A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor Challenge

5. An immunogenic personal neoantigen vaccine for patients with melanoma

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