Integrating Drug’s Mode of Action into Quantitative Structure–Activity Relationships for Improved Prediction of Drug-Induced Liver Injury-Reference-Cited by-同舟云学术

Integrating Drug’s Mode of Action into Quantitative Structure–Activity Relationships for Improved Prediction of Drug-Induced Liver Injury

Published:2017-04-10 Issue:4 Volume:57 Page:1000-1006
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Wu Leihong¹,Liu Zhichao¹,Auerbach Scott²,Huang Ruili³,Chen Minjun¹,McEuen Kristin⁴,Xu Joshua¹,Fang Hong¹,Tong Weida¹^ORCID

Affiliation:

1. National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR RD, Jefferson, Arkansas 72079, United States

2. Division of the National Toxicology Program, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, RTP, North Carolina 27709, United States

3. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

4. University of Arkansas at Little Rock, 2801 S University Ave, Little Rock, Arkansas 72204, United States

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.6b00719

Reference52 articles.

1. In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans

2. Drug Safety Sciences and the Bottleneck in Drug Development

3. Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles

4. Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data

5. Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)

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