Conformational Properties of the Chemotherapeutic Drug Analogue Epothilone A: How to Model a Flexible Protein Ligand Using Scarcely Available Experimental Data-Reference-Cited by-同舟云学术

Conformational Properties of the Chemotherapeutic Drug Analogue Epothilone A: How to Model a Flexible Protein Ligand Using Scarcely Available Experimental Data

Published:2019-03-11 Issue:5 Volume:59 Page:2218-2230
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Dolenc Jožica¹^ORCID,van Gunsteren Wilfred F.²,Prota Andrea E.¹,Steinmetz Michel O.¹³^ORCID,Missimer John H.¹

Affiliation:

1. Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland

2. Laboratory of Physical Chemistry, Swiss Federal Institute of Technology, ETH, CH-8093 Zurich, Switzerland

3. University of Basel, Biozentrum, CH-4056 Basel, Switzerland

Funder

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00171

Reference46 articles.

1. Microtubule-binding agents: a dynamic field of cancer therapeutics

2. Recent Developments in the Chemical Biology of Epothilones

3. Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

4. High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

5. Much Anticipated-The Bioactive Conformation of Epothilone and Its Binding to Tubulin

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