Diameter Is a Key 3D Characteristic for Assessments of Efficient Inhibitors of Protein–Protein Interactions
Author:
Affiliation:
1. Genome Pharmaceutical Institute Company, Ltd., 1-27-8-1207 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
2. Center for Comprehensive Genomic Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
Funder
Japan Society for the Promotion of Science
Publisher
American Chemical Society (ACS)
Subject
Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.0c00607
Reference33 articles.
1. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality
2. Hot spot-based design of small-molecule inhibitors for protein–protein interactions
3. Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions
4. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
5. Atomic Analysis of Protein-Protein Interfaces with Known Inhibitors: The 2P2I Database
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