1. The Knight Cardiovascular Institute, Oregon Health Science University Portland, Portland, Oregon 97239, United States
2. Medicinal Chemistry Core, Oregon Health Science University Portland, Portland, Oregon 97239, United States
3. Department of Anesthesiology & Perioperative Medicine, Oregon Health Science University Portland, Portland, Oregon 97239, United States
4. Pharmaceutical Science Laboratory and Structural Bioinformatics Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520 Turku, Finland