New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative-Reference-Cited by-同舟云学术

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

Published:2019-12-06 Issue:2 Volume:60 Page:756-765
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Rossino Giacomo¹,Orellana Ivana²,Caballero Julio²^ORCID,Schepmann Dirk³,Wünsch Bernhard³^ORCID,Rui Marta¹,Rossi Daniela¹,González-Avendaño Mariela²,Collina Simona¹^ORCID,Vergara-Jaque Ariela²⁴⁵^ORCID

Affiliation:

1. Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy

2. Center for Bioinformatics and Molecular Simulation, Universidad de Talca, 1 Poniente, 1141 Talca, Chile

3. Institute of Pharmaceutical and Medicinal Chemistry, University of Muenster, Correnstrasse 48, 48149 Münster, Germany

4. Multidisciplinary Scientific Nucleus, Universidad de Talca, 1 Poniente, 1141 Talca, Chile

5. Millennium Nucleus of Ion Channels-associated Diseases (MiNICAD), Santiago, Chile

Funder

Universit? degli Studi di Pavia

Consejo Nacional de Innovaci?n, Ciencia y Tecnolog?a

Fondo Nacional de Desarrollo Cient?fico y Tecnol?gico

Ministero dell'Istruzione, dell'Universit? e della Ricerca

Millennium Institutes and Nucleus

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00649

Reference64 articles.

1. The sigma-1 receptor chaperone as an inter-organelle signaling modulator

2. An update on the development of drugs for neuropsychiatric disorders: focusing on the σ1receptor ligand

3. Exon-Intron Structure, Analysis of Promoter Region, and Chromosomal Localization of the Human Type 1 σ Receptor Gene

4. Sigma-1 receptor knockout mice display a depressive-like phenotype

5. Behavioural phenotyping of knockout mice for the sigma-1 (σ1) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations

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