SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern-Reference-Cited by-同舟云学术

SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern

Published:2021-09-01 Issue:9 Volume:61 Page:4687-4700
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Triveri Alice¹,Serapian Stefano A.¹,Marchetti Filippo¹,Doria Filippo¹,Pavoni Silvia²,Cinquini Fabrizio³,Moroni Elisabetta⁴,Rasola Andrea⁵,Frigerio Francesco²,Colombo Giorgio¹^ORCID

Affiliation:

1. Department of Chemistry, University of Pavia, Via Taramelli 12, Pavia 27100, Italy

2. Department of Physical Chemistry, R&D Eni SpA, Via Maritano 27, San Donato Milanese, Milan 20097, Italy

3. Upstream & Technical Services—TECS/STES—Eni Spa, Via Emilia 1, San Donato Milanese, Milan 20097, Italy

4. Istituto di Scienze e Tecnologie Chimiche “Giulio Natta”—SCITEC, CNR Via Mario Bianco 9, Milano 20131, Italy

5. Department of Biomedical Sciences, University of Padua, Viale G. Colombo 3, Padova 35131, Italy

Funder

Fondazione Cassa di Risparmio di Padova e Rovigo

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00857

Reference77 articles.

1. What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs

2. Mechanisms of Protein Sequence Divergence and Incompatibility

3. The robustness and innovability of protein folds

4. The Evolutionary Potential of Phenotypic Mutations

5. SARS-CoV-2 escaped natural immunity, raising questions about vaccines and therapies

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