Smallest Maximum Intramolecular Distance: A Novel Method to Mitigate Pregnane Xenobiotic Receptor Activation-Reference-Cited by-同舟云学术

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Smallest Maximum Intramolecular Distance: A Novel Method to Mitigate Pregnane Xenobiotic Receptor Activation

Published:2020-03-04 Issue:4 Volume:60 Page:2091-2099
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Bower Michael J.¹^ORCID,Aronov Alex M.¹,Cleveland Thomas¹,Hariparsad Niresh¹,McGaughey Georgia B.¹^ORCID,McMasters Daniel R.¹^ORCID,Zhang Xiaodan¹,Goldman Brian¹

Affiliation:

1. Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00692

Reference35 articles.

1. P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

2. Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

3. CYTOCHROME P-450 3A4: Regulation and Role in Drug Metabolism

4. The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

5. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

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1. Induction of human hepatic cytochrome P-450 3A4 expression by antifungal succinate dehydrogenase inhibitors;Ecotoxicology and Environmental Safety;2024-05

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