Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor-Reference-Cited by-同舟云学术

Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor

Published:2021-07-12 Issue:7 Volume:61 Page:3696-3707
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Kelly Brendan¹,Hollingsworth Scott A.¹^ORCID,Blakemore David C.²,Owen Robert M.³^ORCID,Storer R. Ian³,Swain Nigel A.³^ORCID,Aydin Deniz¹,Torella Rubben⁴,Warmus Joseph S.²,Dror Ron O.¹^ORCID

Affiliation:

1. Departments of Computer Science, Molecular and Cellular Physiology, and Structural Biology & Institute for Computational and Mathematical Engineering, Stanford University, Stanford, California 94305, United States

2. Pfizer Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States

3. Pfizer Medicine Design, The Portway, Granta Park, Cambridge CB21 6GS, U.K.

4. Pfizer Medicine Design, 610 Main Street, Cambridge, Massachusetts 02139, United States

Funder

Pfizer

National Institute of General Medical Sciences

European Molecular Biology Organization

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00585

Reference61 articles.

1. The Role of Science in Addressing the Opioid Crisis

2. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

3. Non-Analgesic Effects of Opioids: Opioid-induced Respiratory Depression

4. Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

5. μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Art and Science of Molecular Docking;Annual Review of Biochemistry;2024-08-02

2. Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development;Molecules;2024-06-03

3. Intracellular pocket conformations determine signaling through the μ opioid receptor;2024-04-03

4. Stereoselective recognition of morphine enantiomers by μ-opioid receptor;National Science Review;2024-01-22

5. Biased Signaling in Mutated Variants of β₂-Adrenergic Receptor: Insights from Molecular Dynamics Simulations;Journal of Chemical Information and Modeling;2024-01-09