Comparison of the Cytotoxicity of the Nitroaromatic Drug Flutamide to Its Cyano Analogue in the Hepatocyte Cell Line TAMH: Evidence for Complex I Inhibition and Mitochondrial Dysfunction Using Toxicogenomic Screening-Reference-Cited by-同舟云学术

Comparison of the Cytotoxicity of the Nitroaromatic Drug Flutamide to Its Cyano Analogue in the Hepatocyte Cell Line TAMH: Evidence for Complex I Inhibition and Mitochondrial Dysfunction Using Toxicogenomic Screening

Published:2007-08-17 Issue:9 Volume:20 Page:1277-1290
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Coe Kevin J.¹,Jia Yankai¹,Ho Han Kiat¹,Rademacher Peter¹,Bammler Theo K.¹,Beyer Richard P.¹,Farin Frederico M.¹,Woodke Libby¹,Plymate Stephen R.¹,Fausto Nelson¹,Nelson Sidney D.¹

Affiliation:

1. Departments of Medicinal Chemistry, Environmental Health, Medicine, Pathology, University of Washington, Seattle, Washington 98195, Phillip Morris, Richmond, Virginia 23261, Centre for Molecular Medicine, Singapore 138673, and VAPSHCS, Seattle, Washington 98108

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx7001349

Reference64 articles.

1. Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients

2. Flutamide Hepatotoxicity

3. A review of the common properties of drugs with idiosyncratic hepatotoxicity and the “multiple determinant hypothesis” for the manifestation of idiosyncratic drug toxicity

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