Identification of the First Inhibitor of the GBP1:PIM1 Interaction. Implications for the Development of a New Class of Anticancer Agents against Paclitaxel Resistant Cancer Cells

Author:

Andreoli Mirko1,Persico Marco2,Kumar Ajay3,Orteca Nausicaa2,Kumar Vineet4,Pepe Antonella4,Mahalingam Sakkarapalayam5,Alegria Antonio E.6,Petrella Lella7,Sevciunaite Laima7,Camperchioli Alessia7,Mariani Marisa1,Di Dato Antonio2,Novellino Ettore2,Scambia Giovanni8,Malhotra Sanjay V.4,Ferlini Cristiano1,Fattorusso Caterina2

Affiliation:

1. Danbury Hospital Research Institute, 24 Hospital Avenue, Danbury, Connecticut 06810, United States

2. Department of Pharmacy, University of Napoli “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy

3. School of Environmental Affairs, Universidad Metropolitana, Avenue Ana G. Mèndez, San Juan, Puerto Rico PR 00928, United States

4. Laboratory of Synthetic Chemistry, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, 1050 Boyles Street, Frederick, Maryland 21702, United States

5. Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States

6. Department of Chemistry, University of Puerto Rico at Humacao, 100 Road 908, Humacao, Puerto Rico PR 00791, United States

7. Laboratory of Molecular Oncology, Jean Paul IInd Research Foundation, Largo A. Gemelli 1, 86100 Campobasso, Italy

8. Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Roma, Italy

Funder

Ministero dell'Istruzione, dell'Università e della Ricerca

Associazione Oppo e le sue stanze ONLUS

National Center for Research Resources

National Institute of General Medical Sciences

Connecticut State

National Cancer Institute

European Commission

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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