A New Catalytic Cross-Coupling Approach for the Synthesis of Protected Aryl and Heteroaryl Amidines

Author:

Kusturin Carrie L.1,Liebeskind Lanny S.1,Neumann William L.1

Affiliation:

1. Chemistry and Process Technology, Pharmacia Corporation, 800 North Lindbergh, St. Louis, Missouri, and Department of Chemistry, Emory University, 1515 Pierce Drive, Atlanta, Georgia 30322

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference8 articles.

1. Zablocki, J. A.; Miyano, M.; Garland, R.; Pireh, D.; Schretzman, L.; Rao, S. N.; Lindmark, R. J.; Panzer-Knodle, S. G.; Nicholson, N. S.; Taite, B. B.; Salyers, A. K.; King, L. W.; Campion, J. G.; Feigen, L. P.J. Med. Chem.1993,36, 1811. Greenhill, J. V. ; Lue, P. InAmidines and Guanidines inMedicinal Chemistry, Progress in Medicinal Chemistry; Ellis, G. P., Luscombe, D. K., Eds.; Elsevier:  New York, 1993; Vol. 30, Chapter 5, pp 203−326.

2. For an excellent review, see:  Yet, L. A Survey of Amidine Synthesis. Technical Report No. 3, Vol. 4, 2000; Albany Molecular Research, Inc., New York.

3. Heteroaromatic Thioether−Boronic Acid Cross-Coupling under Neutral Reaction Conditions

4. Substituted Alkyne Synthesis under Nonbasic Conditions:  Copper Carboxylate-Mediated, Palladium-Catalyzed Thioalkyne−Boronic Acid Cross-Coupling

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