N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis-Reference-Cited by-同舟云学术

N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis

Published:2009-07-16 Issue:15 Volume:52 Page:4757-4773
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nuti Elisa¹,Casalini Francesca¹,Avramova Stanislava I.¹,Santamaria Salvatore¹,Cercignani Giovanni²,Marinelli Luciana³,La Pietra Valeria³,Novellino Ettore³,Orlandini Elisabetta¹,Nencetti Susanna¹,Tuccinardi Tiziano¹⁴,Martinelli Adriano¹,Lim Ngee-Han⁵,Visse Robert⁵,Nagase Hideaki⁵,Rossello Armando¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy

2. Dipartimento di Biologia, Unità di Biochimica, Università di Pisa, Via San Zeno 51, 56127 Pisa, Italy

3. Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli “Federico II”, Via Domenico Montesano 49, 80131 Napoli, Italy

4. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122

5. Department of Matrix Biology, The Kennedy Institute of Rheumatology Division, Imperial College, London W6 8LH, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900261f

Reference67 articles.

1. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification

2. Prevention of progressive joint destruction in adjuvant induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR217840

3. Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

4. Matrix Metalloproteinases as Valid Clinical Target

5. Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects

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