Tetramethylcyclopropyl Analogue of a Leading Antiepileptic Drug, Valproic Acid. Synthesis and Evaluation of Anticonvulsant Activity of Its Amide Derivatives

Author:

Sobol Eyal1,Bialer Meir1,Yagen Boris1

Affiliation:

1. Department of Pharmaceutics and Department of Natural Products and Medicinal Chemistry, Faculty of Medicine, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel, and David R. Bloom Centre for Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference64 articles.

1. Bourgeois, F. D. B. Valproic Acid:  Clinical Efficacy and Use in Epilepsy. InAntiepileptic Drugs, 5th ed.; Levy, R. H., Mattson, R. H., Meldrum, B. S., Perucca, E., Eds.; Lippincott Williams & Wilkins Publishers:  New York, 2002; pp 808−817.

2. Silberstein, D. S. Valproic Acid:  Clinical Efficacy and Use in Other Neurological Disorders. InAntiepileptic Drugs, 5th ed.; Levy, R. H., Mattson, R. H., Meldrum, B. S., Perucca, E., Eds.; Lippincott Williams & Wilkins Publishers:  New York, 2002; pp 818−827.

3. Swann, C. A. Valproic Acid:  Clinical Efficacy and Use in Psychiatric Disorders. InAntiepileptic Drugs, 5th ed.; Levy, R. H., Mattson, R. H., Meldrum, B. S., Perucca, E., Eds.; Lippincott Williams & Wilkins Publishers:  New York, 2002; pp 828−836.

4. Valproate and Valproate-Analogues: Potent Tools to Fight Against Cancer

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