AlphaFold2 and Deep Learning for Elucidating Enzyme Conformational Flexibility and Its Application for Design-Reference-Cited by-同舟云学术

AlphaFold2 and Deep Learning for Elucidating Enzyme Conformational Flexibility and Its Application for Design

Published:2023-06-06 Issue:6 Volume:3 Page:1554-1562
ISSN:2691-3704
Container-title:JACS Au
language:en
Short-container-title:JACS Au

Author:

Casadevall Guillem¹,Duran Cristina¹,Osuna Sílvia¹²^ORCID

Affiliation:

1. Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Maria Aurèlia Capmany 69, 17003 Girona, Spain

2. ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Spain

Funder

Ministerio de Ciencia e Innovaci?n

Ministerio de Econom?a y Competitividad

Human Frontier Science Program

Generalitat de Catalunya

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Chemistry (miscellaneous),Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jacsau.3c00188

Reference78 articles.

1. Improved protein structure prediction using potentials from deep learning

2. Structural biology is solved — now what?

3. Highly accurate protein structure prediction with AlphaFold

4. ‘It will change everything’: DeepMind’s AI makes gigantic leap in solving protein structures

5. Fast track to structural biology

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Computational Insights into the Regioselectivity of 1,3-Dipolar Cycloadditions inside Carbon Nanotubes;The Journal of Physical Chemistry C;2024-09-01

2. Advancing microbial production through artificial intelligence-aided biology;Biotechnology Advances;2024-09

3. AlphaFold two years on: Validation and impact;Proceedings of the National Academy of Sciences;2024-08-12

4. Integration of a Randomized Sequence Scanning Approach in AlphaFold2 and Local Frustration Profiling of Conformational States Enable Interpretable Atomistic Characterization of Conformational Ensembles and Detection of Hidden Allosteric States in the ABL1 Protein Kinase;Journal of Chemical Theory and Computation;2024-06-12

5. Directed Evolution of Protoglobin Optimizes the Enzyme Electric Field;Journal of the American Chemical Society;2024-06-07