Improving the In Vivo Therapeutic Index of siRNA Polymer Conjugates through Increasing pH Responsiveness-Reference-Cited by-同舟云学术

Improving the In Vivo Therapeutic Index of siRNA Polymer Conjugates through Increasing pH Responsiveness

Published:2014-01-10 Issue:2 Volume:25 Page:296-307
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Guidry Erin N.¹²,Farand Julie¹²,Soheili Arash¹²,Parish Craig A.¹²,Kevin Nancy J.¹²,Pipik Brenda¹²,Calati Kathleen B.¹²,Ikemoto Nori¹²,Waldman Jacob H.¹²,Latham Andrew H.¹²,Howell Bonnie J.¹²,Leone Anthony¹²,Garbaccio Robert M.¹²,Barrett Stephanie E.¹²,Parmar Rubina Giare¹²,Truong Quang T.¹²,Mao Bing¹²,Davies Ian W.¹²,Colletti Steven L.¹²,Sepp-Lorenzino Laura¹²

Affiliation:

1. Department of Process Chemistry and ∥Department of Analytical Chemistry, Merck & Co. Inc., , Rahway, New Jersey, United States

2. Department of Medicinal Chemistry, §Department of RNA Biology, and ⊥Department of Pharmaceutical Sciences, Merck & Co. Inc., West Point, Pennsylvania, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc400442p

Reference54 articles.

1. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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5. The promises and pitfalls of RNA-interference-based therapeutics

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