Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione-S-transferase P1-1-Reference-Cited by-同舟云学术

Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione-S-transferase P1-1

Published:2012-10-10 Issue:11 Volume:25 Page:2532-2541
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Boerma Jan Simon¹,Dragovic Sanja¹,Vermeulen Nico P. E.¹,Commandeur Jan N. M.¹

Affiliation:

1. Division of Molecular Toxicology, LACDR, Vrije Universiteit, Amsterdam, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx300334w

Reference46 articles.

1. Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

2. Biotransformation of Diclofenac Sodium (Voltaren®) in Animals and in Man.: II. Quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile

3. Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

4. Immunochemical Identification of Mouse Hepatic Protein Adducts Derived from the Nonsteroidal Anti-Inflammatory Drugs Diclofenac, Sulindac, and Ibuprofen

5. Metabolic Activation and Immunochemical Localization of Liver Protein Adducts of the Nonsteroidal Anti-inflammatory Drug Diclofenac

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