Impact of Bile Salts on Solution Crystal Growth Rate and Residual Supersaturation of an Active Pharmaceutical Ingredient
Author:
Affiliation:
1. Preformulation, MRL, Merck & Co., Inc., West Point, Pennsylvania 19486, United States
2. Department of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, United Kingdom
Funder
Merck
Publisher
American Chemical Society (ACS)
Subject
Condensed Matter Physics,General Materials Science,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.cgd.7b00464
Reference49 articles.
1. A Win–Win Solution in Oral Delivery of Lipophilic Drugs: Supersaturation via Amorphous Solid Dispersions Increases Apparent Solubility without Sacrifice of Intestinal Membrane Permeability
2. Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
3. Improving drug solubility for oral delivery using solid dispersions
4. Physical chemistry of supersaturated solutions and implications for oral absorption
5. Combined Use of Crystalline Salt Forms and Precipitation Inhibitors to Improve Oral Absorption of Celecoxib from Solid Oral Formulations
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