In Situ Characterization of Waters of Hydration in a Variable-Hydrate Active Pharmaceutical Ingredient Using 35Cl Solid-State NMR and X-ray Diffraction

Author:

Hirsh David A.1ORCID,Holmes Sean T.2,Chakravarty Paroma3ORCID,Peach Austin A.2,DiPasquale Antonio G.3,Nagapudi Karthik3,Schurko Robert W.2ORCID

Affiliation:

1. Department of Chemistry & Biochemistry, University of Windsor, Windsor, Ontario N9B 3P4, Canada

2. Department of Chemistry & Biochemistry, Florida State University, Tallahassee, Florida 32308, United States

3. Department of Small Molecule Pharmaceutical Sciences, Genentech, Inc., South San Francisco, California 94080, United States

Funder

Canada Foundation for Innovation

Genentech

University of Windsor

Ontario Innovation Trust

Natural Sciences and Engineering Research Council of Canada

Florida State University

Publisher

American Chemical Society (ACS)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Reference59 articles.

1. Brittain, H. G.; Morris, K. R.; Boerrigter, S. X. M. In Polymorphism in Pharmaceutical Solids; Brittain, H. G., Ed. CRC Press, 2009; pp 233–281.

2. Byrn, S. R.; Zografi, G.; Chen, X. S. In Solid State Properties of Pharmaceutical Materials; John Wiley & Sons: Hoboken, 2017; pp 38–47.

3. Pharmaceutical hydrates

4. Griesser, U. J. In Polymorphism; Hilfiker, R., Ed. Wiley-VCH: Weinheim, FRG, 2006; pp 211–233.

5. Morris, K. R. In Drugs and the Pharmaceutical Sciences; Dekker: New York, NY, 1999; pp 125–181.

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