Probes for Narcotic Receptor Mediated Phenomena. 39. Enantiomeric N-Substituted Benzofuro[2,3-c]pyridin-6-ols: Synthesis and Topological Relationship to Oxide-Bridged Phenylmorphans-Reference-Cited by-同舟云学术

Probes for Narcotic Receptor Mediated Phenomena. 39. Enantiomeric N-Substituted Benzofuro[2,3-c]pyridin-6-ols: Synthesis and Topological Relationship to Oxide-Bridged Phenylmorphans

Published:2009-07-24 Issue:23 Volume:52 Page:7570-7579
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Yi¹,Lee Yong Sok²,Rothman Richard B.³,Dersch Christina M.³,Deschamps Jeffrey R.⁴,Jacobson Arthur E.¹,Rice Kenner C.¹

Affiliation:

1. Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, Maryland 20892-9415

2. Center for Molecular Modeling, Division of Computational Bioscience, CIT, National Institutes of Health, DHHS, Bethesda, Maryland 20892

3. Clinical Psychopharmacology Section, Chemical Biology Research Branch, National Institute on Drug Abuse, Addiction Research Center, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224

4. Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, D.C. 20375

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9004225

Reference23 articles.

1. Probes for Narcotic Receptor Mediated Phenomena. 38. An Expeditious Synthesis of rac-cis-4a-Ethyl-2-methyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ol and rac-cis-2-Methyl-4a-phenethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ol

2. Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity

3. Probes for narcotic receptor mediated phenomena. 4. Synthesis of (.+-.)-2,3,4,5,6,6a-hexahydro-3-methyl-8-hydroxy-1H-4,11b-methanobenzofuro[3,2-d]azocine, an oxide-bridged 5-(m-hydroxyphenyl)morphan

4. Probes for narcotic receptor mediated phenomena. 6. Synthesis of (.+-.)-(1.alpha.,4a.alpha.,9a.beta.)-1,3,4,9a-tetrahydro-2-methyl-2H-1,4a-propanobenzofuro[2,3-c]pyridin-8-ol, an oxide-bridged 5-(3-hydroxyphenyl)morphan

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