1. Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China, State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China, and Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China